儿童扩张型心肌病发病机制及治疗进展

Advance in pathogenesis and therapy of pediatric dilated cardiomyopathy

儿童扩张型：心肌病是病因复杂多样的心肌疾病，包括遗传和非遗传的多种发病机制。卡维地洛具有非选择性β受体阻滞作用同时有α1受体阻滞作用，在改善心肌收缩力、抑制心室重构等方面具有突出功能，广泛用于成年人心功能不全治疗，该文对儿童扩张型心肌病发病机制和卡维地洛对其治疗的新进展进行综述。

Dilated cardiomyopathy （DCM） is the most commom form of cardiomyopathy in children, including genetic and non-genetic pathogenesis. Due to the unclear aetiology and pathogenesis, DCM seriously impairs the quality of patients＇ life and reduces patients＇ survival time. Heart failure is one of the main clinical manifestations of DCM. Carvedilol, the third generation of β-adrenergic receptor blocker, is a nonselective β-blocker and a selective α1-blocker as well. It can prevent the development of ventrieular remodeling and improve myocardial contractility and has been widely used in treating chronic cardiac insufficiency in adults. This article summarized some new progresses in pathogenesis and therapy of pediatric dilated cardiomyopathy.