真菌生物被膜的研究进展

Research advence of hiofilms of Aspergillus

真菌生物被膜对患者病死率的影响已经逐渐引起临床医师的重视。产生生物被膜的真菌中，白色念珠菌最为人们熟知，同时，非念珠菌属，如酵母菌类的新型隐孢子菌以及霉菌类的烟曲霉菌也可以引起生物被膜相关感染。真菌生物被膜独特的生长过程，包括黏附、定植、增殖和播散，都有复杂的分子作用机制。强有力的抗真菌治疗仍然是对付真菌生物被膜的最有效的办法。

The mortality causing by fungal biofilms has already made doctors pay attention to Candida albicans is the most famous one of all fungal biofilm formers. However, non-Candida species, yeasts such as Cryptococcus neoformans, and filamentous moulds such as Aspergillus fumigatus, have been shown to be implicated in biofilm associated infections. Fungal biofilms have distinct developmental phases, including adhesion, colonisation, maturation and dispersal, which are governed by complex molecular events. Recalcitrance to antifungal therapy remains the greatest threat to patients with fungal biofilms.