阻沫回收分离器在阿维菌素发酵中的应用

A broth-froth recovery seperator application in avermectins production by Streptomyces avermitilis

目的研究一种新型阻沫回收分离器在农用抗生素阿维菌素工业发酵生产中的应用。方法阿维菌素发酵过程中，应用一种基于泡沫旋风分离与发酵尾气再回收相结合原理的新型阻沫回收分离器。结果放罐系数由原来月平均的65％提高至80％左右，体积增加率为22．47％，显著提高了发酵罐的利用率；单位罐产量（总亿）比月平均单罐产量提高了20．54％；在发酵过程尾气回收方而，每罐批比对照罐能回收利用9％～10％的排放尾气，减少了发酵污染物的排放。结论这种新型阻沫回收分离器可显著提高阿维菌素发酵过程中的放罐系数，还可能应用到其它发酵液性能相似的生物发酵产品。

Objective To apply a novel broth-froth recovery separator （BFRS） in agro-antibiotic avermectins production by Streptomyccs avermitilis on an industrial scale. Method A novel broth-froth recovery seperator, which was made based on the principle of foam cyclone separation coupling with exhauset gas recycling, was introduced in avermectins fermentation. Results The working capacity was significantly increased by 22.47% from 65% （control） up to 80%, resulting in a higher utilization efficiency for the productive fermenter. Also, the total avermectin yield per batch of the fermenter coupling with BFRS was enhanced by 20.54% than the mean monthly avermectin yield per batch obtained without BFRS application. Regarding the exhaust gas recycling performance of the BFRS, 9%-10% of the outlet gas could be reused during avermectin fermentation process, resulting in a significant reduction of total outlet gas emission and of pollutants produced by S. avermitilis cultured in a 120M3 fermenter. Conclusion The BFRS can remarkably enhance the fermenter＇s working capacity, and it can be applied in other bioproduct production with a similar broth＇s characterization.