摘要
以乙酰苯胺和4-氯二苯甲酮为起始原料,经多步反应方便而有效地合成了二苯基哌嗪磺胺化合物,所得目标化合物及其中间体的结构经1HNMR、13CNMR、IR、MS谱和元素分析等证实.研究了化合物的体外抗微生物活性,结果表明目标化合物14和16对所测菌株的抗菌活性均优于磺胺.
The novel diphenyl piperazine-based sulfanilamides were conveniently and efficiently synthesized via multi-step reactions starting from commercially available acetanilide and （4-chlorophenyl）（phenyl）methanone. The synthesized title compounds and their intermediates were characterized by 1H NMR, 13C NMR, IR and MS spectra as well as elemental analyses and screened in vitro for their antibacterial and antifungal activities. The antimicrobial activity showed that the target compounds 14 and 16 exhibited better inhibitory potency than sulfanilamide against all tested bacterial strains.
出处
《中国科学：化学》
CAS
CSCD
北大核心
2011年第3期451-460,共10页
SCIENTIA SINICA Chimica
基金
西南大学人才引进基金(SWUB2006018)
西南大学高新技术培育基金(XSGX0602)
重庆市自然科学基金(CSCT2009BB5296)
国家人事部回国人员重点项目(2002-99)资助
关键词
磺胺
哌嗪
三唑
抗微生物
抗菌
sulfanilamide
piperazine
triazole
antimicrobial
antibacterial
