多环百部生物碱Stemonamine的全合成

An efficient total synthesis of Stemonamine

以新颖的环氧醇串联Semipinacol重排/Schmidt反应为关键步骤,设计发展了高效构筑含有氮杂季碳中心的[5,5,7]三环骨架1的方法.本文从关键中间体1出发,设计了关键的酮酯缩合反应构筑D环的方法,经过7步转化,高效、高选择性地完成了蔓生百部碱Stemonamine的全合成.

A short and efficient approach to the Stemona alkaloids has been developed. The representative members, Stemonamine, has been synthesized from the known key intermediate 1 in 7 steps and 47.3% overall yield featured by a novel ketone-ester condensation to forge the spirolactone ring.