盐酸头孢唑兰的结构确证

Structural confirmation of cefozopran hydrochloride

目的:建立利用仪器分析盐酸头孢唑兰化学结构的方法。方法:通过元素分析仪分析盐酸头孢唑兰的元素组成,并利用核磁共振(NMR)、质谱(MS)、红外光谱(IR)对盐酸头孢唑兰进行结构分析。结果:通过实验证实盐酸头孢唑兰的结构为(6R,7R)-7-[(Z)-2-(5-氨基-1,2,4-噻二唑-3-基)-2-甲氧亚氨基乙酰胺基]-3-(1H-咪唑并[1,2-b]哒嗪-4-嗡-1-基-甲基)-8-氧代-5硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-乙酸内盐单盐酸盐。结论:该方法准确可行,可为以后盐酸头孢唑兰的结构鉴定提供依据。

Objective：To establish a method for the determination of the chemical structure of cefozopran hydrochloride.Method：Elemental analysis（EA）,nuclear magnetic resonance（NMR）,the infrared spectra（IR） and the MS were adopted to analyze the chemical structure of cefozopran hydrochloride.Result：The chemical structure of cefozopran hydrochloride is（6R,7R）-7-[（Z）-2-（5-amino-1,2,4-thiadiazol-3-yl）-2-methoxyiminoacetylamino]-3-（1H-imidazo[1,2-b]pyridazin-4-ium-1-ylmethyl）-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid chloride.Conclusion：The result of the method is accurate,general and can provide a comprehensive reference for production and identification of cefozopran hydrochloride.