胆管癌分子病理学研究进展

Research progress on molecular pathology of cholangiocarcinoma

胆管癌早期诊断困难，预后差，其发生、发展和转移扩散的分子机制仍不明确。全球胆管癌发病率和病死率的增加，迫切需要阐明引发胆管上皮恶性转化和胆管恶性肿瘤生长的细胞内机制。对胆管癌分子病理学进行更完善的描述，有助于找到诊治这种破坏性恶性肿瘤的有效靶点。文中综述近年来在胆管癌变分子进程认识上的科学进展。

The early diagnosis of cholangiocarcinoma is difficult, and the prognosis is poor. The molecular mechanisms underlying the development, growth and metastatic spread of biliary tract cancers are still unclear. The increase in worldwide incidence and mortality of cholangiocarcinoma justifies the impellent need to clarify the intracellular mechanisms triggering the malignant transformation of the biliary epithelium and growth of biliary malignancies. A more complete characterization of the molecular pathology of bile duct cancers could lead to the identification of valid targets for diagnosis and therapy of these devastating malignancies. This review describes the scientific progress made over the past years with regard to the understanding of the molecular processes of cholangiocarcinogenesis.