高强度聚焦超声（HIFU）肿瘤热消融技术的关键问题简析

Analysis of key problem of high intensity focused ultrasound （HIFU） thermal ablation technique

目的 1988年，王智彪萌发了用高强度聚焦超声（highintensity focused ultrasound，HIFU）从体外对体内肿瘤进行非侵入切除的灵感。在之后的10年中，他和他的团队在该领域提出了“生物学焦域”、“超声治疗剂量学”、“组织声环境”等概念。在实时超声监控、治疗系统优化、远程医疗系统、临床方案等方面突破了相应的关键技术壁垒。将HIFU治疗技术成功运用于外科治疗，在国际上积累了数量最多的临床病例。在该领域的设备研制、临床应用及若干基础研究方面走在了世界前列。

In 1988, Zhibiao Wang had an inspiration of ablating tumor in vivo non-invasively by high intensity fo- cused ultrasound （HIFU）. In the following 10 years, he and his team first proposed concepts such as ＂biological focal region＂, ＂ ultrasound therapy dosimetry＂, ＂ acoustic environment in tissue＂ and so on. They had broken down the key technical barriers in real-time ultrasound monitoring, treatment system optimization, telemedicine system, clinical protocols and other aspects, making HIFU therapy successfully applied to surgery and accumulated the largest number of clinical cases internationally. They have been playing a leading role around the world in equipment development, clinical application and some basic research in this field.