摘要
变异链球菌是龋病的主要病原菌之一,变异链球菌表面蛋白对细菌在牙面的初始黏附及菌体之间的聚集起重要作用。有研究证实表面蛋白抗原Ⅰ/Ⅱ的阳性免疫与抗蛋白P1单克隆抗体的阴性免疫都能抑制变异链球菌致龋,因此表面蛋白P1已被看作龋病疫苗开发的潜在抗原[1]。该文就P1结构中的脯氨酸富集区(P区)、丙氨酸富集区(A区)及两者之间的相互作用对P1的免疫原性、稳定性和表面表达等方面的影响作一综述。
Streptococcus mutans is the major etiological agent of human dental caries.Surface protein of S.mutans plays an important role in the initial bacterial adhesion to tooth surface and bacterial aggregation.Many studies confirmed that active immunization with antigenn I/II and passive immunization with anti-protein P1 monoclonal antibody can inhibit dental caries caused by Streptococcus mutans.Therefore,P1 has been identified as a potential antigen for the development of dental caries vaccine.In this paper,the contribution of alanine-rich region,proline-rich region,and the interaction between the two regions,to antigenicity,stability and surface expression of P1 is summarized.
出处
《牙体牙髓牙周病学杂志》
CAS
北大核心
2011年第2期106-109,共4页
Chinese Journal of Conservative Dentistry
关键词
变异链球菌
表面蛋白
脯氨酸富集区
丙氨酸富集区
Streptococcus mutans
surface protein
proline-rich region
alanine-rich region
