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钙联蛋白调控内质网应激诱导的细胞凋亡 被引量：7

Calnexin modulates cellular apoptosis induced by endoplasmic reticulum stress
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摘要 内质网应激(ERS)可诱导多种细胞凋亡,与疾病发生发展密切相关。钙联蛋白(CNX)是内质网中重要的类凝集素分子伴侣,通过参与未折叠蛋白反应募集凋亡相关因子、激活IRE1-JNK激酶等途径,调控ERS诱导的凋亡。本文就其研究现状进行阐述。 Endoplasmic reticulum stress（ERS） could induce apoptosis of mamy kinds of cell,that is relative closely with disease development.Calnexin,a kind of chaperon in endoplasmic reticulum,could modulate the apoptosis induced by ERS via several pathway invovling UPR,recruiting apoptosis-related factor and activating IRE1-JNK.
作者 李爱玲 修瑞娟
机构地区 中国医学科学院北京协和医学院微循环研究所
出处 《基础医学与临床》 CSCD 北大核心 2011年第3期335-338,共4页 Basic and Clinical Medicine
关键词 内质网应激 钙联蛋白 细胞凋亡 endoplasmic reticulum stress calnexin apoptosis
分类号 R363 [医药卫生—病理学]
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参考文献15

  • 1Hosoi T, Ozawa K. Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities [ J ]. Clin Sci (Lond), 2009, 118:19 -29.
  • 2Salminen A, Kauppinen A, Suuronen T, et al. ER stress in Alzheimer's disease: a novel neuronal trigger for inflanunation and Alzheimer's pathology [ J ]. J Neuroinflammation, 2009, 26:41 -54.
  • 3Prins D, Michalak M. Endoplasmic reticulum proteins in cardiac development and dysfunction [ J ]. Can J Physiol Pharmacol, 2009, 87:419 - 425.
  • 4Rasheva VI, Domingos PM. Cellular responses to endoplasmic reticulum stress and apoptosis [ J ]. Apoptosis, 2009, 14:996 - 1007.
  • 5Guerin R, Turcotte C, Leroux A, et al. The epigenetic calnexin-independent state is induced in response to environmental changes [ J ]. FEMS Yeast Res, 2009, 9 : 1250 - 1259.
  • 6Delom F, Fessart D, Chevet E, et al. Regulation of calnexin sub-cellular localization modulates endoplasmic reticulum stress-induced apoptosis in MCF-7 ceils [ J ]. Apoptosis, 2007,12:293 - 305.
  • 7Xu D, Perez RE, Rezaiekhaligh MH, et al. Knockdown of Erp57 increases BiP/GRP78 induction and protects against hyperoxia and tunicamycin-induced apoptosis [J]. Am J Physiol Lung Cell Mol Physiol, 2009,297 :L44 -51.
  • 8Zhao C, Shono M, Sun A, et al. Constitutive expression of an endoplasmic reticulum small heat shock protein alleviates endoplasmic reticulum stress in transgenic tomato[J]. J Plant Physiol, 2007,164:835-841.
  • 9Guerin R, Arseneault G, Dumont S, et al. Calnexin is involved in apoptosis induced by endoplasmie reticulum stress in the fission yeast [ J ]. Mol Biol Cell, 2008,19 : 4404 - 4420.
  • 10Coe H, Bedard K, Groenendyk J, et al. Endoplasmic reticulum stress in the absence of calnexin [ J ]. Cell Stress Chaperones, 2008,13:497 - 507.

同被引文献72

  • 1Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress [ J ]. Nat Cell Biol. 201l, 13 (3) : 184 - 190.
  • 2Quadrilatero J, Bombardier E, Norris SM, et al. Prolonged moderate- intensity aerobic exercise does not alter apoptotic signaling and DNA fragmentation in human skeletal muscle [ J ]. Am J Physiol Endocrinol Metab. 2010, 298(3) :E534 -547.
  • 3Carraro U, Franceschi C. Apoptosis of skeletal and cardiac muscles and physical exercise [J]. Aging Milano). 1997; 9(1 -2) :19 -34.
  • 4Phaneuf S, Leeuwenburgh C. Apoptosis and exercise [J]. Med Sci Sports Exerc. 2001, 33 (3) :393 - 396.
  • 5Saido TC, Sorimachi H, Suzuki K. Calpain: new perspectives in molecular diversity and physiological- pathological involvement [J]. FASEB J. 1994, 8(11):814 -822.
  • 6Xu C, Bailly -Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions [J]. J Clin Invest. 2005, 115 (10) :2656 -2664.
  • 7Bollo M, Paredes R M, Holstein D, et al. Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs[J]. PLoS One, 2010, 5(8) : e11925.
  • 8Aremu D A, Ezomo O F, Meshitsuka S. Gene expression in primary cultured astrocytes affected by aluminum: alteration of chaperons in- volved in protein folding[ J]. Environ Health Prev Med, 2011, 16 (1): 16-24.
  • 9Malhotra J D, Miao H, Zhang K, et al. Antioxidants reduce endoplas- mic reticulum stress and improve protein secretion[ J]. Proc Natl Acad Sei USA, 2008, 105 (47) : 18525 - 18530.
  • 10Pfaffenbach K T, Gentile C L, Nivala A M, et al. Linking endoplas- mic reticulum stress to cell death in hepatocytes: roles of C/EBP ho- mologous protein and chemical chaperones in palmitate-mediated cell death[J]. Am J Physiol Endocrinol Metab, 2010, 298(5) : E1027 - E1035.

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基础医学与临床
2011年 第3期

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