相容性溶质四氢嘧啶及其羟基化衍生物的研究进展

Compatible Solutes Ectoine and Its Derivate Hydroxyectoine

四氢嘧啶类化合物是嗜盐以及耐盐菌胞内合成的一类能够抵御外界高盐胁迫的相容性溶质,概述了四氢嘧啶及其衍生物的理化特征以及在嗜盐微生物中抵御外界高渗透压的作用机理,主要阐述了四氢嘧啶类相容性溶质的生物合成途径、膜运输机理、分泌释放机制、高密度发酵生产等方面在细胞、分子水平上的最新研究进展以及前景展望。并且综述了四氢嘧啶类在精细化工、生物医药及生物制造等行业的应用研究以及发展前景,探讨了未来的研究方向。

Ectoine and its derivatives are de novo synthesized by halophilic or halotolerant bacteria as compatible solutes. The characteristic of ectoines in biochemical and physiological role of osmotic stress defence in microorganisms was introduced, the protective properties of ectoines for cells were descirbed and transferred to enzyme, nucleic acid, and human skin etc. Data were analyzed and summarized in the synthesis pathway of ectoines and transporters system in the halophilic bacteria on the cell and molecular level, and the production of ectoines by halophic bacteria was described, such as downshock and milking process. In addition, the applications of ectoines were also summarized, which would be useful in the field of biology industry, medicine treatment and cosmetic for prevent aging of skin etc.