T细胞免疫球蛋白黏蛋白分子3与慢性病毒感染

T cell immunoglobulin mucin 3 and chronic virus infection

T细胞免疫球蛋白黏蛋白分子3（Tim-3）为主要表达于T细胞表面的受体蛋白,可以激活Tim-3/Galectin-9（Tim-3L）信号通路导致淋巴细胞功能障碍甚至凋亡.HIV、HCV等病毒慢性感染时Tim-3在T细胞表达上调,而阻断Tim-3/Galectin-9通路可以部分恢复T细胞功能.因此,Tim-3表达可能与病毒感染慢性化的发生有关,此文就Tim-3与病毒感染慢性化的关系进行综述.

T cell immunoglobulin mucin 3（Tim-3） is a receptor protein expressing on T cells surface,interacting between Tim-3 and its ligand-Galectin-9（Tim-3L） which inhibits lymphocyte responses,even induces apoptosis.Researches find that the expression of Tim-3 is increased on T cells in chronic viral infection,and blockade of the Tim-3/Galectin-9 signaling pathway can rescue part of the T lymphocyte function.Now,it is considered that Tim-3 could be closely related to chronic viral infection,and the relation between them is reviewed in this article.