期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

SIRT1与成体干细胞衰老 被引量：5

SIRT1 and adult stem cell senescence
下载PDF
导出
摘要 成体干细胞(adult stem cells)具有自我更新功能并可以分化为执行特定功能的体细胞,维持组织和器官结构完整和功能健全。有研究显示衰老可以出现在成体干细胞水平,并与机体老龄化及损伤修复能力下降有关。哺乳动物沉默调节因子2相关酶1(Sirtuins 1,SIRT1)是NAD+依赖性蛋白去乙酰化酶。对体细胞的研究表明,提高SIRT1活性可以抗细胞衰老。近年来,成体干细胞的相关研究表明SIRT1可能具有平衡干细胞的静息与增殖、维持干细胞自我更新功能、缓解年龄相关性成体干细胞功能下降和抑制成体干细胞分化紊乱的作用,但其抗衰老的分子机制还有待进一步研究。 stem cells differentiate into a variety of somatic cells which perform particular functions,in order to maintain integrity of specific tissues and organs during their lifespan.Studies have shown that senescence,which contributes to aging and the weakness under stress,occurs in adult stem cells.Sirtuins 1（SIRT1） is a NAD＋-dependent deacetylase in mammalian cells.Activated SIRT1 may have anti-senescence effects on somatic cells,as well as in adult stem cells through balancing stem cell quiescence and proliferation,maintaining self-renewal capacity,ameliorating age-related decline in stem cell function and diminishing differentiation bias.Molecular mechanisms underlying SIRT1 anti-senescence ability still require to be investigated.
作者 翟志斌 孟爱民
机构地区 北京协和医学院
出处 《中国药理学通报》 CAS CSCD 北大核心 2011年第1期140-142,共3页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No81072237) 国家重点基础研究发展计划(973计划)资助项目(No2011CB964800)
关键词 SIRT1 去乙酰化 成体干细胞 衰老 静息态 自我更新 分化 SIRT1 deacetylation adult stem cells senescence quiescence self-renew differentiation
分类号 R-05 [医药卫生] R329.24 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献10

  • 1Brunet A,Sweeney L B,Sturgill J F,et al.Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase[J].Science,2004,303(5666):2011-5.
  • 2Kaeberlein M,McVey M,Guarente L.The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms[J].Genes Dev,1999,13(19):2570-80.
  • 3Tothova Z,Kollipara R,Huntly B J,et al.FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress[J].Cell,2007,128(2):325-39.
  • 4Han M K,Song E K,Guo Y,et al.SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization[J].Cell Stem Cell,2008,2(3):241-51.
  • 5Boily G,Seifert E L,Bevilacqua L,et al.SirT1 regulates energy metabolism and response to caloric restriction in mice[J].PLoS One,2008,3(3):e1759.
  • 6Wang Y,Schulte B A,LaRue A C,et al.Total body irradiation selectively induces murine hematopoietic stem cell senescence[J].Blood,2006,107(1):358-66.
  • 7Meng A,Wang Y,Brown S A,et al.Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and-independent mechanisms[J].Exp Hematol,2003,31(12):1348-56.
  • 8Berthiaume M,Boufaied N,Moisan A,et al.High levels of oxidative stress globally inhibit gene transcription and histone acetylation[J].DNA Cell Biol,2006,25(2):124-34.
  • 9Luo J,Nikolaev A Y,Imai S,et al.Negative control of p53 by Sir2alpha promotes cell survival under stress[J].Cell,2001,107(2):137-48.
  • 10李德冠,孟爱民.造血干细胞衰老机制研究[J].中国药理学通报,2008,24(6):701-704. 被引量：13

二级参考文献25

  • 1Linton P J, Dorshkind K. Age-related changes in lymphocyte development and function [ J ]. Nature Immunol, 2004,5 (2) : 133 - 9.
  • 2Lichtman M A, Rowe J M. The relationship of patient age to the pathobiology of the clonal myeloid diseases [ J ]. Semin Oncol, 2004,31(2) :185 -97.
  • 3Kollman C, Howe C W, Anasetti C, et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age[J]. Blood, 2001, 98(7) :2043 -51.
  • 4Allsopp R C, Weissman I L. Replicative senescence of hematopoietic stem cells during serial transplantation : does telomere shortening play a role[J] ? Oncogene, 2002,21(21 ) :3270 -3.
  • 5Rossi D J, Bryder D, Weissman I L. Hematopoietie stem cell aging: mechanism and consequence [ J ]. Exp Gerontol, 2007,42 (5) :385 -90.
  • 6Chambers S M, Shaw C A, Gatza C, et al. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation [J]. Plos Biol, 2007,5(8) :e201.
  • 7Janzen V, Forkert R, Fleming H E, et al. Stemcell ageing modified by the cyclindependent kinase inhibitor p16INK4a[ J]. Nature, 2006,443(7110) :421 -6.
  • 8Meng A, Wang Y, Van Zant G, Zhou D. Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells [ J ]. Cancer Res, 2003,63 ( 17 ) :5414 - 9.
  • 9Wang Y, Schulte B A, Larue A C, et al. Total body irradiation selectively induces murine hematopoietic stem cell senescence[ J ].Blood, 2006,107(1) :358 -66.
  • 10Meng A, Wang Y, Brown S A, et al. Ionizing radiation and busulfan inhibit murine bone marrow cell hematopoietic function via apoptosis-dependent and -independent mechanisms [ J ]. Exp Hematol, 2003,31( 12 ) :1348 -56.

共引文献12

同被引文献79

  • 1Hyun-Seok Kim a., 1., Eui-ju Yeo b., 1., Seong-Hoon Park et al. p21WAF/CIPI/SDI1 is upregulated due to increased mRNA stability duringhydroxyurea-induced senescence of hu- man fibroblasts. Mechanisms of Aging and Development 2005, 126:1255-- 1261.
  • 2Wang W., Furneaux H., Caldwell M.C. et al. HuR regulates p21WAF/CIPI/SDII mRNA stabilization by [IV light.Mol. Cell. Biol. 2000,20: 760 - 769.
  • 3Wang W.. Yang X.. Cristofalo. Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Molecular and Cellular Biology, 2001, 21(17): 5889--5898.
  • 4Wengong Wang, Jennifer L Martindale, Xiaoling Yang. et al. Increased stability of the p16 mRNA with replicative senesce- nce.EMBO Rep. February. 2005,6(2):158--164.
  • 5Kyle Lafferty-Whyte, Claire J. Cairney, Nigel B. et al. Path- way analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanis- ms. Biochimica et Biophysica Acta (BBA) - Molecular Ba- sis of Disease, 2009,1792(4):341--352.
  • 6Guorong Li, Coralia Lunaa, Jianming Qiua et al. Alterations in micro RNA expression in stress-induced cellular senescen- ce. Mechanisms of Ageing and Development, 2009, 130, ( 11- 12) :731--741.
  • 7Kyle Lafferty-Whyte, Claire J. Cairney, Nigel B. et al. Path- way analysis of senescence-associated miRNA targets reve- als common processes to different senescence induction mec- hanisms. Biochimica et Biophysica Acta (BBA)- Molecular Basis of Disease, 2009, 1792(4):341--352.
  • 8Kotb Abdelmohsen, Subramanya Srikantan, Yuki Kuwano et al. miR-519 reduces cell proliferation by lowering RNA- binding protein HuR levels. Proceedings of the National Acade- my of Sciences of the United States of America. 2008,23(12); 105(51):20297--20302.
  • 9Takashi Ito, Shusuke Yagi, Munekazu Yamakuchi. Micro R- NA-34a regulation of endothelial senescence. Biochemical and Biophysical Research Communications, 2010, 398,(6): 735 --740.
  • 10Pittenger MF,MackayAM,Beck SC. Multilineage potential of adult human mesenchymal stem cells[J].Science,1999,(5411):143-147.doi:10.1126/science.284.5411.143.

引证文献5

二级引证文献15

中国药理学通报
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部