环糊精衍生物的点击化学合成法的研究进展

Progress on Cyclodextrin Derivatives Synthesized via "Click" Chemistry

点击化学("click"chemistry)具有反应条件温和、选择性高、产率高、纯化步骤简单等优点,现已成为当前的一大研究热点.环糊精具有"内疏水、外亲水"的锥筒状空腔结构,是超分子化学的重要主体之一,合成功能各异的环糊精衍生物引起了人们的广泛关注.综述了点击反应合成环糊精衍生物的最新研究进展及其应用,并对其发展前景做了展望.

＂Click＂ chemistry has become a hot issue in present because of their mild reaction conditions,high selectivity,high yields and simple purification steps.Cyclodextrin and their derivatives（CDs） having skirt-shaped cyclic oligosaccharides with a hydrophobic inner cavity and a hydrophilic outside surface are important hosts of supramolecular chemistry.Synthesizing CDs with various properties has gained much at-tention.In this paper,CDs synthesized via ＂click＂ reaction and their applications are reviewed.Based on these reviews,the prospect is discussed.