石藤胶囊对类风湿性关节炎患者OPG和RANKL的影响

The Effect of Shiteng Capsules on OPG and RANKL of Patients with Rheumatoid Arthritis

目的:观察石藤胶囊对类风湿性关节炎患者骨保护素(osteoprotegerin,OPG)、核因子κB受体激活配体(re-ceptor activator of NF-κB ligand RANKL)的影响。方法:入选类风湿性关节炎患者随机分为治疗组(30例)和对照组(30例),治疗组用石藤胶囊,对照组用雷公藤多苷,两组同时配以甲氨蝶呤,均服药90天,观察治疗前后两组患者的OPG、RANKL变化。结果:治疗后两组血清RANKL均有明显降低(P<0.05),OPG均有明显提高(P<0.05),两组间比较RANKL和OPG均无统计学意义(P>0.05)。结论:石藤胶囊可以降低类风湿性关节炎患者血清RANKL水平,提高血清OPG水平。

Objective ：To observe the effect of Shiteng capsules to osteoprotegerin （OPG） and receptor activator of NK - KB ligand （RANKL） of the patients with RA. Methods ：The patients with RA were divided into randomly treatment team（30cases） that was treated with Shiteng capsules and control team（30 cases）that was treated with tripterygium glycosides. Two teams were treated in methotrexate at the same time. All patients were taken 90 days. The changes of the OPG and RANKL were observed in two teams before and after treatment. Results ： Blood serum RANKL are low obviously in two teams （ P 〈 0. 05）. OPG are high obviously after treatment（ P 〈 0. 05 ）. There are not statistically significant in RANKL and OPG between two teams （P 〉 0. 05 ）. Conclusion ： Shiteng capsules can cut down the level of the blood serum RANKL and boost the level of the blood serum OPG of the patients with RA.