基于代谢组学的中药“组效关系”研究思路与策略

Research on the Basic Idea and Strategy of Combination-Activity Relationship in Chinese Materia Medica by Metabolomics

中药药效物质组合与药效活性的关联性即"组效关系"是中药现代研究的关键科学问题之一。本文提出了基于代谢组学的中药"组效关系"研究的基本策略,即基于药物代谢物组学的有效成分辨识,基于代谢组学的有效成分组合的药效活性评价,基于系统建模的有效成分组合与药效活性之间关联性分析。该策略的提出,对于创新中药质量评价模式、阐释方剂配伍规律、创制组分中药具有重要意义。

Combination-Activity Relationship （CAR）, which refers to the relation between combinations and activities of active components in Chinese Materia Medica （CMM）, is one of the key scientific study aspects in the modernization of CMM. In this paper, the basic research strategy of CAR based on metabolomics was put forward. This strategy includes active components identification based on pharmaco-metabonomics, pharmacodynamic activity evaluation based on metabolomics, and correlation analysis of active component combinations and their pharmacodynamic activities based on systems modeling. This study supplied theoretical and technical support for improving quality evaluation mode for CMM and multi-component Chinese medicine, and explaining mechanism of synthetical function and compatibility law of CMM prescription.