注射用活血通络中超临界CO_2萃取川芎脂溶性成分的工艺研究

Studies on Extraction of Fat-soluble Ingredients from Ligusticum Chuanxiong of Injected Huoxue Tongluo by Supercritical Fluid Extraction

目的:优选注射用活血通络中超临界CO_2萃取川芎脂溶性成分的工艺条件。方法:以川芎脂溶性成分得率和藁本内酯、阿魏酸的含量为指标,采用正交试验法优选超临界CO_2萃取川芎脂溶性成分的工艺条件。结果:最佳工艺条件:萃取温度50℃,压力35MPa,时间1h。结论:该提取工艺条件稳定可行。

The study aimed to optimize the conditions of supercritical fluid extraction for fat-soluble ingredients of Ligusticum chuanxiong Hort. The fat-soluble ingredients, content of Ligustilide, and content of ferulic acid were used as the indexes in this study. The extraction technology for fat-soluble ingredient of Ligusticum chuanxiong Hort was optimized by the orthogonal design. Results showed that the optimal extraction conditions were at the temperature of 50 ℃, and the pressure of 35 Mpa for one hour. The conclusion is that the extraction technology was stable and feasible.