摘要
中药新药设计在中药新药研发中占有重要地位,对提升新药创制水平具有重大意义。本文围绕"组效关系",提出了中药新药设计的概念、研究框架及技术方法,将处方发现、成分辨识和组方优化作为中药新药设计的核心与关键,以期为中药新药创制提供理论和技术支撑。
Design of New Drug of Chinese Medicine （DNDCM） is very important in the research and development of new drug in Chinese medicine. DNDCM will improve the level of new drug research and development in Chinese medicine. In this paper, we put forward the conception, research frameworks and technical routes of DNDCM centering on Combination-Activity Relationship （CAR）. In addition, prescription discovery, component identification and prescription optimization are the core and key of DNDCM, which will be expected to offer the theoretical and technological support for R＆D of new drug in Chinese medicine.
出处
《世界科学技术-中医药现代化》
2011年第1期154-158,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家科技支撑计划项目(2008BAI51B03):基于有效成分群的中药组方设计技术研究
子课题负责人:杨洪军
国家重大新药创制专项(2009ZX09301-005):综合性中药新药研究开发技术大平台
负责人:曹洪欣
中国中医科学院基本科研业务费自主选题项目(Z02063):确有疗效中药
方剂的活性物质基础及其组效关系研究
负责人:杨洪军
关键词
中药新药设计
组效关系
处方发现
成分辨识
组方优化
系统建模
Design of New Drug of Chinese Medicine, Combination-Activity Relationship, Prescription discovery,Component identification, Prescription optimization, System modeling
