模拟微重力效应对辐射致细胞DNA损伤修复效应的影响

Effects of Modeled Microgravity on DNA Repair of Lymphocytes Induced by Ne Ions

在地面模拟微重力的情况下,应用碱性单细胞凝胶电泳(SCGE)技术对80 MeV/u Ne离子辐射诱发人血淋巴细胞DNA损伤修复效应进行了研究。在不同时刻对相同剂量辐照后的淋巴细胞经单细胞电泳处理后显示,在模拟微重力下孵育的彗星尾更长,彗星头面积更小。这表明,相对地面环境而言,模拟微重力环境对淋巴细胞的DNA损伤修复有一定的抑制作用。

Effect of the modeled microgravity（MMG） on heavy ion-induced lymphocytes DNA repair by using single cell gel electrophoresis（SCGE） has been studied.The results showed that residual DNA damage induced by Ne ions irradiation increased more in cultures incubated in MMG than in 1 g,which indicated that MMG incubation after Ne ions irradiation reduce the DNA damage repair capacity.