摘要
猪圆环病毒2型(PCV2)DNA的复制是滚环复制,Rep和Rep′蛋白是PCV复制所必需的蛋白质,核心元件A*TA*TAC为必需的结合位点。复制的影响因素包括病毒内部因素如病毒基因内的CpG寡核苷酸和干扰素反应元件、病毒黏附受体(硫酸乙酰肝素和硫酸软骨素B乙糖胺)和病毒内吞作用(小GTP酶和肌动蛋白);外部因素如DL-硒蛋氨酸和刀豆素A。抑制PCV2复制的措施有猪营养的全面,干扰RNA技术,疫苗的使用等。
The replication of PCV2 was rolling-circle replication,the replication proteins Rep and Rep′ of porcine circovirus type 2 were essential for viral replication in transfected cells,the key sequence A＊TA＊TAC was the essential binding site for Rep an Rep′.The influencing factors included interior factors such as CpG motifs and interferon-stimulated response element in viral gene,attachment receptors（heparan sulfate and chondroitin sulfate B glycosaminoglycans）,viral internalization（small GTPases and actin）;and exterior factors such as dl-selenomethionine and ConA.The strategy for controlling PCV2 included all-around nutrition,RNA interference and useage of accines.
出处
《中国畜牧兽医》
CAS
北大核心
2011年第3期220-223,共4页
China Animal Husbandry & Veterinary Medicine
