盐酸法舒地尔与低分子肝素联合治疗急性后循环脑梗死的临床研究

Clinical study on union treatment of acute posterior circulation infarction with fasudil hydrochloric and low molecular weight heparin

目的观察盐酸法舒地尔与低分子肝素钠联合治疗急性后循环脑梗死(POCI)的治疗效果。方法随机将95例急性后循环脑梗死病人分为两组:治疗组50例,对照组45例。在常规治疗基础上,治疗组用盐酸法舒地尔注射液60mg加入250ml生理盐水静脉点滴每日1次、低分子肝素钠6000u皮下注射每日2次,疗程均14d;对照组用依达拉奉注射液30mg加入100ml生理盐水静脉点滴每日2次、低分子肝素钠6000u皮下注射每日2次,疗程均14d。治疗前后定期对患者进行欧洲脑卒中量表(ESS)、日常生活能力(ADL)和常规检查,以治疗第14d ESS增分率和第90d ADL(Barthe1)评分作为主要疗效判断标准。结果治疗14d后,ESS增分率分别为(42.5±10.2,28.3±7.8),治疗组与对照组相比有极显著性差异(P<0.01),ADL评分治疗组与对照组相比也有极显著性差异(P<0.01)。结论盐酸法舒地尔与低分子肝素联合治疗后循环脑梗死临床疗效显著,安全可靠,可在后循环脑梗死的急性期应用。

Objective To investigate union treatment effects of fasudil hydrochloric and low molecular weight heparin sodium on acute posterior circulation infarction.Methods This trial selected 95 acute posterior circulation infarction patients which were divided into two groups treatment group（50 cases） and control group（45 cases） randomly.Based on routine therapy and low molecular weight heparin sodium 6000U,i.h,bid,treatment group received fasudil hydrochloric 60mg,i.v.gtt,qd and control group received edaravone 30mg,i.v.gtt,bid,totally 14 days.Measure The European Stroke Scale（ESS） and Activities of Daily Living（ADL）and routine examine of fore-and-aft treatment,compare these two groups ESS increments of after treatment on 14th day and ADL（Barthe1） Scores of after treatment on 90th day to study most effect.Results After treatment on 14th,ESS increments of treatment group and control group are（42.5±10.2）,（28.3±7.8）,they have very marked difference（P〈0.01）;ADL（Barthe1） Scores were elevated very markedly compared with that of control group（P〈0.01）.Conclusions Clinical union treatment effects of fasudil hydrochloric and low molecular weight heparin on acute posterior circulation infarction were marked,safe and effective,can apply in the acute time of posterior circulation infarction.