冠心病患者血清中血管内皮细胞生长因子与超敏C反应蛋白的变化及临床意义

Serum of patients with coronary vascular endothelial growth factor and high sensitivity C reactive protein and clinical significance

目的研究血管内皮细胞生长因子和超敏C-反应蛋白在冠心病患者血清中的变化及其临床意义。方法将76例冠心病患者分为稳定型心绞痛组(1组)、不稳定型心绞痛组(2组)、急性心肌梗死组(3组)和陈旧性心肌梗死组(4组),每组19例,同时设19例健康对照组。应用酶联免疫吸附法分别检测血清血管内皮细胞生长因子和超敏C-反应蛋白水平。结果冠心病患者血清血管内皮细胞生长因子和超敏C-反应蛋白水平升高具有正相关性,均高于对照组(P<0.05)。血管内皮细胞生长因子水平各组之间差别均有统计学意义(P<0.05);超敏C-反应蛋白水平除1组与4组之间差别无统计学意义外,其他各组之间比较差别均有统计学意义(P<0.05)。结论血管内皮细胞生长因子和超敏C-反应蛋白水平可以反映了冠心病患者的病情变化,二者联合检测对预测冠心病的病变程度、判断预后有一定价值。

Objective To study the vascular endothelial growth factor and high sensitive C-reactive protein in serum of patients with coronary heart disease and its clinical significance.Methods 76 patients with CHD were divided into stable angina（group 1）,unstable angina（group 2）,acute myocardial infarction（group 3） and old myocardial infarction（4） n = 19 cases,while 19 cases of healthy controls set.Respective enzyme-linked immunosorbent assay of serum vascular endothelial growth factor and high sensitive C-reactive protein levels.Results In coronary heart disease vascular endothelial growth factor and ultra-sensitive C-reactive protein levels were positively correlated,were higher（P〈0.05）.Vascular endothelial growth factor levels in each group were statistically significant differences between（P〈0.05）;high sensitive C-reactive protein levels in addition to Group 1 and 4 no significant difference between groups,all other comparisons between groups differences were statistically significant（P〈0.05）.Conclusions The vascular endothelial growth factor and high sensitive C-reactive protein level can reflect changes in coronary heart disease patients,the two combined detection of the severity of coronary heart disease prediction,prognosis have a certain value.