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梅尼埃病的遗传学研究进展 被引量：1

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摘要 梅尼埃病(Meniere's Disease,MD)是一种特发性内耳慢性疾病,病因复杂,目前尚无定论。随着遗传学及基因技术的发展,遗传因素在梅尼埃病发病中的作用研究受到越来越多的重视。本文结合近年来国内外文献,对梅尼埃病的遗传学特征及相关基因的研究作一综述。
作者 张婷 戴春富
机构地区 复旦大学附属眼耳鼻喉科医院耳鼻喉科
出处 《中国眼耳鼻喉科杂志》 2011年第1期58-60,共3页 Chinese Journal of Ophthalmology and Otorhinolaryngology
关键词 遗传学特征 梅尼埃病 慢性疾病 基因技术 遗传因素 相关基因 特发性 国内外
分类号 R764 [医药卫生—耳鼻咽喉科]
  • 相关文献

参考文献23

  • 1Morrison AW,Mowbray JF,Williamson R,et al.On genetic and environmental factors in Meniere's disease[J].Am J Otol,1994,15(1):35-39.
  • 2Watanabe Y,Mizukoshi K,Shojaku H,et al.Epidemiological and clinical characteristics of Meniere's disease in Japan[J].Acta Otolaryngol Snppl,1995,519(2):206-210.
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  • 5Frykholm C,Larsen HC,Dahl N,et al.Familial Mé nière's disease in five generations[J].Otol Neurotol,2006,27(5):681-686.
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  • 9Koo JW,Oh SH,Chang SO,et al.Association of HLA-DR and type Ⅱ collagen autoimrannity with Meniere's disease[J].Tissue Antigen,2003,61(1):99-103.
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二级参考文献14

  • 1Robertson NG, Skvorak AB, Yin Y, et al. Mapping and characterization of a novel Cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9. Genomics, 1997, 46:345-354.
  • 2Robertson NG, Lu L, Heller S, et al. Mutation in a novel cochlear gene cause DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Nature Genet, 1998, 20:299-303.
  • 3de Kok Y, Bom SJH, Brunt TM, et al. A Pro51Ser mutation in the COCH gene is associated with late onset autosomal dominant progressive sensorineural hearing loss with vestibular defects. Hum Mol Genet, 1999, 8:161-166.
  • 4Fransen E, Verstreken M, Verhagen WIM, et al. High prevalence of symptoms of Meniere,s disease in three families with a mutation in the COCH gene. Hum Mol Genet, 1999, 8:1425-1429.
  • 5Kamarinos M, McJill J, Lynch M, et al. Identification of a novel COCH mutation, I109N, highlights the similar clinical features observed in DFNA9 families. Hum Mutat, 2001, 17:351.
  • 6Francen E, Verstreken M, Bom SJH, et al. A common ancestor for COCH related cochleovestibular (DFNA9) patients in Belgium and the Netherlands bearing the P51S mutation. J Med Genet, 2001, 38:61-64.
  • 7van Camp G, Smith RJH. Hereditary hearing loss homepage. http://dnalab-www.uia.ac.be/dnalab/hhh.
  • 8Bom SJH, Kunst HPM, Huygen PLM, et al. Nonsyndromal autosomal hearing impairment:ongoing phenotypical characterization of genotypes. Br J Audiol, 1999, 33:335-348.
  • 9Usami S, Takahashi K, Yuge I, et al. Mutations in the COCH gene are a frequent cause of autosomal dominant progressive cochleo-vestibular dysfunction, but not of Meniere,s disease. Eur J Hum Genet, 2003, 11:744-748.
  • 10Verhagen WIM, Bom SJH, Fransen E, et al. Hereditary cochleovestibular dysfunction due to a COCH gene mutation (DFNA9):a follow-up study of a family. Clin Otolaryngol, 2001, 26:477-483.

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中国眼耳鼻喉科杂志
2011年 第1期

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