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B细胞在系统性红斑狼疮发病机制中的作用研究进展 被引量：9

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摘要 系统性红斑狼疮（systemic lupus erythematosus，SLE）是由多种复杂因素共同作用的，可引起个体差异明显的多系统损害、病程迁延反复的典型器官非特异性自身免疫性疾病。其病因及发病机制至今仍未完全明确，可能与遗传、环境、内分泌异常及免疫紊乱等有着密切关系。近几年通过对SLE模型小鼠及人SLE的研究发现，B细胞在SLE发生、发展中可能起到重要作用。
作者 何德宁 董光富
机构地区 广东省医学科学院广东省人民医院风湿免疫科 汕头大学医学院
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2011年第2期133-136,共4页 Chinese Journal of Rheumatology
关键词 系统性红斑狼疮 发病机制 B细胞 ERYTHEMATOSUS 特异性自身免疫性疾病 lupus 多系统损害 内分泌异常
分类号 R593.241 [医药卫生—内科学]
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参考文献25

  • 1Chan OT,Hannum LG,Haberman AM,et al.A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus.J Exp Med,1999,189:1639-1648.
  • 2Anolik J,Sanz I.B cells in human and murine systemic lupus erythematosus.Curr Opin Rheumatol,2004,16:505-512.
  • 3Pugh-Bernard AE,Cambier JC.B cell receptor signaling in human systemic lupus erythematosus.Curr Opin Rheumatol,2006,18:451-455.
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二级参考文献10

  • 1邓筠,王元,唐元家,崔慧娟,郭彦芝,沈南.Toll样受体7及I型干扰素通路在系统性红斑狼疮中的作用研究[J].现代免疫学,2008,28(3):194-198. 被引量：10
  • 2李守新,黄睿,徐咏芬,王晓慧,刘雯,雷小妹.系统性红斑狼疮外周血B淋巴细胞激活及TOLL样受体9表达[J].中华风湿病学杂志,2006,10(2):82-84. 被引量：10
  • 3Berland R, Fernandez L, Kari E, et al. Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity, 2006, 25: 429-440.
  • 4Papadimitraki ED, Choulaki C, Koutala E, et al. Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process. Arthritis Rheum, 2006, 54: 3601-3611.
  • 5Ehlers M, Fukuyama H, McGaha TL, et al. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med, 2006, 203: 553-561.
  • 6Bombardier C, Gladman DD, Urowitz MB, et al. Derivation of the SLEDAI: a disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum, 1992, 35: 630-640.
  • 7Christensen SR, Shupe J, Nickerson K, et al. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity, 2006, 25: 417-428.
  • 8Ito T, Wang YH, Liu YJ. Plasmacytoid dendritic cell precursors/ type Ⅰ interferon-producing cells sense viral infection by Toll- like receptor (TLR) 7 and TLR9. Springer Semin Immunol, 2005, 26: 221-229.
  • 9Migita K, Miyashita T, Maeda Y, et al. Toll-like receptor expression in lupus peripheral blood mononuclear cells. J Rheumatol, 2007, 34: 493-500.
  • 10Ehlers M, Ravetch JV. Opposing effects of Toll-like receptor stimulation induce autoimmunity or tolerance. Trends Immunol, 2007, 28: 74-79.

共引文献4

同被引文献76

引证文献9

二级引证文献33

中华风湿病学杂志
2011年 第2期

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