产妇骨量与新生儿体格关系的研究

The relationship between maternal bone mass and newborn physique

目的探讨产妇的骨量与足月新生儿体格的关系。方法双能X线骨密度仪检测330名20～33岁妇女产后2～3 d时的全身及多部位骨量和骨密度,问卷调查获得孕期营养摄入、生育史、患病史等基本信息,测量新生儿出生时的身长、体重和头围,分析产妇骨量与新生儿体格之间的相关关系。结果在校正了胎龄、产后BMI、孕期能量、蛋白质、钙摄入量等混杂因素后,协方差分析显示新生儿的身长与产妇股骨颈BMC呈明显线性增长趋势(P=0.031),与全身BMC和左侧股骨BMC的线性增长趋势处于临界水平(P=0.068,P=0.063)。新生儿的体重与产妇全身BMC、L1-4 BMC、Ward三角BMC和股骨颈BMC之间呈明显线性增长趋势(P<0.05)。新生儿头围与产妇全身BMC之间呈明显线性增长趋势(P=0.012)。结论新生儿体格发育与母体骨量显著正相关。提高母体骨量,有利于新生儿体格发育。

Objective To assess the relationship between maternal bone mass and newborn physical development. Methods A total of 330 pregnant women aged 20-33 were recruited in Guangdong Women and Children Hospital. Bone mineral density （BMD） and bone mineral content （BMC） at the total-body, lumbar spine and proximal femur were examined with a dual-energy X-ray absorptiometry after 2-3 days of delivery. Basic information was collected via face-to-face interview, including dietary intakes in pregnancy, reproductive history, disease history, etc. Body length, weight and head circumference at birth were measured. Results After adjustment for gestational age, BMI after delivery, intakes of energy, protein and calcium, birth length was positively associated with maternal femoral neck BMC （P = 0. 031 ）. Marginally significant associations of birth length with total body BMC and proximal femur BMC were observed （P = 0. 068,P = 0.063 respectively）. Birth weight was does-independently increased with maternal total body BMC, lumbar spine BMC, Ward＇s triangle BMC and femoral neck BMC （P 〈 0. 05 ）. Birth head circumference was positively associate with maternal total body BMC （P = 0. 012）. Conclusion Newborn anthropometry indices are positively correlated with maternal bone mass.