A型肉毒素治疗特发性眼睑痉挛临床报告

Clinical observation of type A botulismotoxin on blepharospasm patients

目的观察A型肉毒素治疗特发性眼睑痉挛的效果及副作用。方法选择因面神经功能紊乱而致的严重眼睑痉挛患者32例,皮下注射A型肉毒素,对治疗前后的病情分级进行对比,分析治疗效果。结果其中29例(90.62%)患者在注射后眼睑痉挛完全缓解,3例(9.38%)得到明显缓解,有效率100%。23例(71.88%)患者3～5个月后眼睑痉挛复发,再次注射仍然有良好效果。3例患者出现轻中度上睑下垂,1～3周后恢复。结论 A型肉毒素治疗特发性眼睑痉挛的效果确切良好,副作用轻或少,但大多数患者需每隔3～5个月重复注射。

Objective To study the effect and side effect of the botulinum toxin A （BTXA） injection for the treatment of blepharospasm.Methods 32 patients with blepharospasm were injected BTXA with ten-points into convulsive muscle , the effect was analyzed。Results In 32 patients,29 patients （90.62 %） revealed complete effect s,3 patients （9.38 %） revealed marked effect s, The total effective rate was 100 %.23 patients （71.88 %） recued after three month,it was fine after injected secondary. 3 patients （9.38 %）appeared blepharoptosis.All patients feeled eyelid stiffness. All patients don’t feeled hypophasis and anaphylaxis.Conclusion The treatment of the use of the botulinum toxin A（BTXA） to the blepharospasm can improve the cure rate and the side effect was junior,but mostly patients needed injection more time.