牙龈卟啉单胞菌研究进展

Research progress on Porphyromonas gingivalis

牙周炎是常见的口腔疾病之一,是中国成年人失牙的主要原因。牙龈卟啉单胞菌在引发牙周组织破坏过程中发挥着重要的作用,成为国内外学者研究的热点之一。本文就牙龈卟啉单胞菌与口腔疾病和其他全身性疾病的关系、牙龈卟啉单胞菌全基因组、牙龈卟啉单胞菌与牙龈上皮细胞的相互作用等研究作一综述,以拓宽牙龈卟啉单胞菌的研究思路,进而为牙周炎的治疗提供新的靶点。

Periodontitis,one of common oral diseases,was the main reason for tooth loss of adults in our nation. Porphyromonas gingivalis（P.gingivalis） played an important role in periodontal tissue destruction,and became one of the focuses in domestic and foreign scholars＇researches in recent years.This review focused on the researches of the relationship between P.gingivalis and oral diseases,relationship between P.gingivalis and systemic diseases,genome and pathogenicity genes of P.gingivalis,and interaction between P.gingivalis and gingival epithelial cells.This review intends to broaden the view on the researches of P.gingivalis,furthermore,to provide a new objective for periodontal therapy.