乳牙牙髓干细胞库的构建及其研究进展

Research progress on banking stem cells from human exfoliated deciduous teeth

干细胞库是指以人体干细胞移植为目的,具有采集、处理、保存和提供多向分化干细胞能力的储存库,曾被人称为"生命银行"。从个体牙髓中获取干细胞并储存入库备用是一个可行的、相对微创且能取代从其他组织来源获取干细胞的途径。乳恒牙替换是一个正常的生理现象,从脱落的乳牙牙髓中分离培养出干细胞用于储存是建立干细胞库的简单、较易被接受的方法,并为日后治疗机体外伤和病变提供了一个很好的组织工程学种子细胞来源。更重要的是,用个体化的干细胞进行自体移植再生性治疗,能最大限度降低免疫排斥和疾病交叉感染的风险。本文就建立乳牙牙髓干细胞库的设想、研究进展和技术细节作一综述。

Stem cells bank is a repository that collects,preserves and provides stem cells with multi-lineage differentiation.It is used for stem cells transplantation and called ＂life bank＂.Tooth derived cells are readily accessible and provide an easy and minimally invasive way to obtain and store cells for future use that simple alter to harvest stem cells from other tissues.Deciduous tooth exfoliation is a basic physiological process.Obtaining stem cells from human exfoliated deciduous teeth（SHED） is simple and convenient,with little or no trauma. SHED could be needed to treat future injuries or ailments as a new kind of seed cells.Furthermore,using ones own stem cells poses few,if any,risks for immune reactions or the potential disease from donor cells.This review includes the research progress in banking stem cells from SHED and the technique details of it.