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机械力对核心结合因子-α_1的表达和调控

Effect and regulatory mechanisms of mechanical strain on the expression of core binding factor-α_1
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摘要 核心结合因子(Cbf)-α1在骨成型和骨改建过程中起着重要的作用,而机械力则是调控骨改建的一个关键性因素。本文就Cbf-α1的结构、Cbf-α1与骨改建的关系、机械力对Cbf-α1的表达调控等研究进展作一综述。 Core binding factor（Cbf）-α1 is an important transcription factor which is necessary for bone modeling and bone remodeling.Mechanical stress is regarded as a key factor for the regulation of bone remodeling.This article was to review the structure of the Cbf-α1,the relationship between Cbf-α1 and bone remodeling,recent research progress in regulation of mechanical forces on the Cbf-α1 expression.
作者 郭萍 林新平
机构地区 浙江大学医学院附属口腔医院正畸科 浙江中医药大学附属口腔医院正畸科
出处 《国际口腔医学杂志》 CAS 2011年第2期218-220,共3页 International Journal of Stomatology
基金 浙江省自然科学基金资助项目(Y2080370)
关键词 核心结合因子-α1 骨改建 机械力 信号通路 促丝裂原激活蛋白激酶 core binding factor-α1 bone remodeling mechanical stress signal pathway mitogen-activated protein kinase
分类号 R346 [医药卫生—基础医学]
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参考文献21

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国际口腔医学杂志
2011年 第2期

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