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新生儿糖尿病的分子诊断 被引量:5

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摘要 糖尿病在新生儿中极罕见,发生率约1/400000新生儿,常与胰岛素分泌不足有关,50%患儿确诊后需终生治疗,其余表现为暂时性发病,但缓解后有可能复发。新生儿糖尿病(NDM)的病因与儿童期发病的胰岛素依赖型糖尿病不同。近期研究发现,
作者 陈思 肖新华
出处 《中国新生儿科杂志》 CAS 2011年第2期143-144,共2页 Chinese Journal of Neonatology
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同被引文献33

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  • 2Stanik J,Gasperikova D,Paskova M,et al.Prevalence of permanent neonatal diabetes in Slovakia and successful replacement of insulin with sulfonylurea therapy in KCNJ11and ABCC8mutation carriers.J Clin Endocrinol Metab,2007,92:1276-1282.
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  • 6Gloyn AL,Pearson ER,Antcliff JF,et al.Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2and permanent neonatal diabetes.N Engl J Med,2004,350:1838-1849.
  • 7Lin CW,Lin YW,Yan FF,et al.Kir6.2mutations associated with neonatal diabetes reduce expression of ATP-sensitive K+channels:implications in disease mechanism and sulfonylurea therapy.Diabetes,2006,55:1738-1746.
  • 8Molven A,Ringdal M,NordbAM,et al.Mutations in the insulin gene can cause MODY and autoantibody-negative type1diabetes.Diabetes,2008,57:1131-1135.
  • 9Polak M,Dechaume A,CavéH,et al.Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy:a report from the French ND(Neonatal Diabetes)Study Group.Diabetes,2008,57:1115-1119.
  • 10郑晓萍,陈朔晖,陈晓春,等.双"C"治疗一例非钾通道依赖性新生儿糖尿病的护理[A].中华护理学会.全国儿科护理学术交流会议论文汇编[c].中华护理学会,2012:4.

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