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SIGIRR与TLRs信号通路 被引量:6

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摘要 Toll样受体(Toll like receptors,TLRs)是固有免疫系统中的主要病原模式受体之一,TLRs通路的激活在全身性炎症反应和天然防御免疫中起着重要作用[1]。但是过度的TLR应答会引发抗炎与致炎间的失衡导致机体损伤。
出处 《四川医学》 CAS 2011年第3期428-430,共3页 Sichuan Medical Journal
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  • 1Lissauer ME, Johnson SB, Bochicehio GV, et al. Differential expression of Toll-like receptor genes : sepsis compared with sterile inflammation 1 day before sepsis diagnosis [ J]. Shock, 2009, 31 (3): 238 - 244.
  • 2Thomassen E, Renshaw BR, Sims JE. Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily[J]. Cytokine, 1999, 11(6):389-399.
  • 3Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity[J]. Nature, 1997, 388(6640): 394-397.
  • 4Miteham JL, Parnet P, Bonnert TP, et al. T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family[J]. J Biol Chem, 1996, 271(10) : 5777-5783.
  • 5Xiaoxia L, Jinzhong Q. Modulation of Toll-lnterleukinl receptor mediated signaling[J]. J Mol Med, 2005, 83(4) : 258 -266.
  • 6Akira S, Takeda K. Toll-like receptor signaling[ J]. Nat Rev lmmunol, 2004, 4(7) : 499 -511.
  • 7Weighardt H, Holzrnann B. Role of Toll-like receptor responses for sepsis pathogenesis[J]. Immunobiology, 2008, 212(9-10): 715-722.
  • 8Alexopoulou L, Holt AC, Medzhitov R, et al. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 [J]. Nature, 2001, 413(6857) : 732 -738.
  • 9Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity[J]. Cell, 2006, 124(4): 783-801.
  • 10Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defense[J]. Nat Rev lmmunol, 2007, 7(3) : 179 - 190.

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