癌胚抗原受体在非消化器官的表达及意义

Expression of carcinoembryonic antigen receptor in non-digestive organs

目的研究癌胚抗原受体在肺、脑、骨、卵巢等组织中的表达及意义。方法以雌性BALB/c小鼠20只为研究对象,以免疫组化的方法检测肺、脑、骨、卵巢等器官组织中的癌胚抗原受体表达情况,并探讨其肿瘤学意义。结果癌胚抗原受体在室管膜上皮和脉络丛上皮细胞的细胞膜,卵母细胞、卵泡细胞、细支气管黏膜上皮细胞和肺泡细胞的细胞质,骨细胞、部分脑灰质细胞和胶质细胞的细胞核与细胞质中呈阳性表达,而在卵巢结缔组织细胞、脑白质细胞中呈阴性表达。不同阳性细胞的表达强度差异有统计学意义(χ2=64.8,P<0.01),以骨细胞和脑灰质细胞表达强度较高。结论癌胚抗原受体在肺、脑、骨、卵巢等组织中呈差异性表达,可能与癌胚抗原高表达肿瘤的远处转移有关。

Objective To explore the expression of carcinoembryonic antigen receptors（CEAR） in non-digestive organs.Methods All specimens were from 20 female BALB/c mice including lung,brain,bone,ovary,etc.Immunohistochemistry methods were used respectively to detect CEAR in those tissues.Results CEAR was found in membrane of ependymal cells and chaoroid epithelial cells,in cytoplasm of respiratory bronchiole epithelial cells,alveolar cells,oocytes and follicular cells,also in cytoplasm and nuclei of osteocytes,neurons and neuroglial cells in grey matter,while not in connective tissue cells in ovary or neurons and neuroglial cells in white matter.There were significantly differences in the CEAR′s expression intensity（χ2=64.8,P0.01）.The richest CEAR was found in the oocytes and some neurons or neuroglial cells in grey matter.Conclusion There are significant differences in the expression of CEAR in lung,brain,bone and ovary,according to the different tissue and cells,which maybe take an important role in metastasis for those tumors with high CEA expression.