冠心病患者脉搏波速度相关因素探讨

Investigation on relationship between pulse wave velocity and coronary artery disease

目的探讨冠心病患者脉搏波速度(PWV)变化特点及其相关危险因素。方法选取心血管内科住院疑诊冠心病患者59例,根据冠状动脉造影结果分为冠心病组(34例)和非冠心病组(25例),详细收集每例患者相关临床资料,包括患者年龄、性别、血压、心率、左室射血分数(LVEF)、血脂、空腹及餐后2 h血糖等结果。对所有入选者检测臂踝脉搏波速度(baPWV)。结果冠心病组与非冠心病组间baPWV[(1 945.29±251.57)cm/s vs(1 481.76±267.98)cm/s,P<0.01]、TC[(5.31±1.86)mmol/L vs(4.49±0.77)mmol/L,P<0.05]、LDL-C[(2.69±1.09)mmol/L vs(2.20±0.55)mmol/L,P<0.05]、血尿酸(UA)[(388.59±82.60)mmol/L vs(317.24±69.50)mmol/L,P<0.01]及超敏C-反应蛋白(hs-CRP)[(0.69±0.32)vs(0.09±0.52),P<0.01]差异有统计学意义,而其他指标两组间差异无统计学意义(P>0.05)。结论 baPWV与冠心病密切相关,且LDL-C、UA及hs-CRP在冠心病发生、发展中起重要作用。

Objective To investigate the relationship between brachial-ankle pulse wave velocity（baPWV） and coronary artery disease.Methods According to the results of coronary angiography,59 patients were divided into two groups.34 patients had history of coronary heart disease and 25 patients had no coronary heart disease.baPWV was measured,relevant clinical data and blood biochemistry test were collected.Results There were significant differences in baPWV[（1 945.29±251.57）cm/s vs（1 481.76±267.98）cm/s,P0.01],TC[（5.31±1.86）mmol/L vs（4.49±0.77）mmol/L,P0.05],LDL-C[（2.69±1.09）mmol/L vs（2.20±0.55） mmol/L,P0.05],UA[（388.59±82.60） mmol/L vs（317.24±69.50） mmol/L,P0.01] and hs-CRP[（0.69±0.32） vs（0.09±0.52）,P0.01].But there were no significant differences in other clinical data.Conclusion There is close relationship between baPWV and coronary heart disease.LDL-C,UA and hs-CRP play an important role in the occurrence and development of coronary heart disease.