BODE指数在我国农村慢性阻塞性肺疾病患者中的应用价值

Application value of BODE index in patients with chronic obstructive pulmonary disease in rural China

目的探讨我国农村地区慢性阻塞性肺疾病（COPD）患者BODE指数与生活质量的相关性及其应用价值。方法选择广东省英德市九龙镇COPD稳定期患者26例。测定并计算其BODE指数各项目的评分。采用St George呼吸问卷（SGRQ）评价患者的生活质量。结果患者BODE指数分级与SGRQ总分、症状分、活动分、影响分均具有相关性（r值分别为0．674、0．430、0．460、0．495，P均〈0．05）；GOLD分级仅与SGRQ总分和活动分具有相关性（r值分别为0．447、0．418，P均〈0．05）。多元线性逐步回归分析发现BODE指数中影响SGRQ总分的因素是6min步行距离（t=-2．397，P=0．025）和呼吸困难（t=2．257，P=0．034）。结论农村COPD患者BODE指数和生活质量密切相关，BODE指数中6min步行距离和呼吸困难对生活质量的影响最大。

Objective To evaluate the application value of BODE, and the relationship between BODE index and life quality in patients with chronic obstructive pulmonary disease （COPD） in rural China. Methods A total of 26 rural patients with stable COPD were enrolled. BODE index and it＇s four components including body mass index （ BMI ）, airflow obstruction （ FEV1% ）, dyspnea （ MMRC ） and exercise capacity （6MWD） were calculated. St. Georgeps Respiratory Questionnaire （SGRQ） were used to evaluate health-related quality of life of these patients. Results The BODE index was significantly correlated with the SGRQ total score , symptom ,activity and impact score （ r = 0. 674,0. 430,0. 460,0. 495 respectively, Ps 〈 0. 05 ）. GOLD grade was only significantly correlated with the SGRQ total score and active score（ r = 0. 447,0. 418, Ps 〈 0. 05 ）. Stepwise liner multiple regression analysis showed that activity score of SGRQ was an influence factor of BODE index. 6MWD of BODE index（ t = - 2. 397 ,P = 0. 025 ） and MMRC （ t = 2. 257, P = 0. 034 ） were independently correlated with activity scores of SGRQ . Conclusion BODE index and life quality had significant relationship. 6MWD and MMRC of BODE index were the most powerful influence factors of life aualitv in rural COPD patients.