心肌肌钙蛋白Ⅰ在阻塞性睡眠呼吸暂停低通气综合征患儿中的意义

Clinical significance of myocardial Toponin Ⅰ in children obstructive sleep apnea-hypopnea syndrome

目的探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患儿心肌损害的风险。方法在我院住院诊断为腺样体或扁桃体肥大的患儿23例，其中伴OSAHS 15例，不伴OSAHS 8例；选择我院同期健康查体儿童27名为健康对照组。采用化学发光法检测上述患儿和健康儿的血清心肌肌钙蛋白含量，并进行比较。结果伴OSAHS组心肌肌钙蛋白Ⅰ为（0．022±0．009）μg/L，不伴OSAHS组为（0．035±0．012）μg/L，健康对照组为（0．017±0．015）μg/／L。ANOVA分析组间差异有统计学意义（F=8．369，P=0．001），两两比较，健康对照组与伴OSAHS组差异有统计学意义（P〈0．001）。结论患有腺样体和扁桃体肥大伴有OSAHS的儿童，与正常儿童相比有心肌损害。

Objective To investigate the risk of myocardial damage induced by obstructive sleep apnea- hypopnea syndrome （OSAHS） in children. Methods Twenty-three children who were in-hospital patients and diagnosed as adenoidal hypertrophy or palatine tonsil hypertrophy enrolled in the study as cases, among whom 15 cases were affected by OSAHS （OSAHS group） ,and 8 cases were not affected by OSAHS（ no-OSAHS group）. Twenty-seven healthy children from health physical examination were enrolled as controls （control group）. Chemiluminescence was used to detect the value of Troponin Ⅰ（TnI） in all children,and the values of the three groups were compared. Results In the OSAHS group, TnI was （0. 022 ± 0. 009） μg/L; in the non-OSAHS group, TnI was （0.035 ± 0.012） μg/L;in the control group,TnI was （0.017 ± 0.015） μg/L There were significant difference among the three groups （ F = 8. 369,P = 0. 001 ）. Furthermore,compared with the control group,TnI in the OSAHS was significantly higher（ P 〈 0. 001 ）. Conclusion Children with adenoid or tonsil hypertrophy associated with OSAHS in children were found to have myocardial damage compared to healthy children,whereas similar on myocardial damage to children with adenoid and tonsil hypertrophy but not OSAHS.