茶多酚对飞行人员微循环及抗氧化能力的影响

Effects of Tea Polyphenols on Microcirculation and Antioxidation in Aircrew.

目的研究茶多酚（ Ｔｅａ Ｐｏｌｙｐｈｅｎｏｌｓ 简称 Ｔ Ｐ） 对飞行人员球结膜微循环（ Ｂ Ｃ Ｍ） 的影响及抗氧化作用，为飞行人员选择合适的抗氧化保健药品。方法４０ 名健康疗养飞行人员随机分为 Ｔ Ｐ 组（ Ｔ Ｐ６００ ｍｇ／ｄ ， Ｐ Ｏ） ，对照组（ 服安慰剂） ，２０ ｄ 后检测。结果 Ｔ Ｐ 组红细胞超氧化物岐化酶（ Ｓ Ｏ Ｄ）活性， 全血谷光甘肽过氧化物酶（ Ｇ Ｓ Ｈ Ｐ Ｘ） 活性及血清丙二醛（ Ｍ Ｄ Ａ） 含量比值 Ｇ Ｓ Ｈ Ｐ Ｘ／ Ｍ Ｄ Ａ明显高于对照组（ Ｐ＜ ０ ．０１） ， Ｍ Ｄ Ａ 明显低于对照组（ Ｐ＜ ０ ．０５） 。 Ｔ Ｐ 组 Ｂ Ｃ Ｍ 微血管数明显增加（ Ｐ＜ ０ ．０１） ；微血流速度明显加快（ Ｐ＜ ０ ．０５） ； 轻中度红细胞聚集明显减轻（ Ｐ＜ ０ ．０５） ； 缺血区明显减少（ Ｐ＜ ０ ．０１） ； Ａ／ Ｖ 比值明显变小（ Ｐ＜ ０ ．０１） ； Ｂ Ｃ Ｍ 总积分值明显低于对照组（ Ｐ＜ ０ ．０１） 。结论 Ｔ Ｐ能提高飞行人员抗氧化能力，减少 Ｂ Ｃ Ｍ 变异，改善其微循环状态。

Objective To study the effects of tea polyphenols (TP) on bulbi conjunctiva microcirculation (BCM) and antioxidation in aircrew and find out the proper antioxidant for the health protection of aircrew. Method Fourty healthy aircrew were divided into TP group (TP 600 mg/d.po) and control group (placebo) randomly. The effects of TP on microcirculation and antioxidation in aircrew were tested after 20 days. Result Red blood cell (RBC) superoxide dismutase (SOD) activity and GSH-PX (Whole blood glutathione peroxidase)/MDA (serum malondialdehyde) ratio in TP group were significantly higher than those in control (P<0.01), and serum MDA level was significantly decreased after TP administration (P<0.05). The numbers of capillaries and blood flow in micrangium were significantly increased, RBC aggregation, ischemia area and A(arteriole)/V(venule) ratio were remarkably decreased in TP group(P<0.01) . The total integral value of microcirculation in TP group was significantly reduced in comparison with that in the control group. Conclusion TP can significantly increase the antioxidative ability of aircrew , decrease the BCM disturbance and improve the microcirculatory function.