联合检测胸水D-二聚体、癌胚抗原对恶性胸腔积液的诊断价值

Value of D-dimer and CEA in pleural effusions from malignant perfusions

目的探讨联合检测胸水D-二聚体（D—dimer，D—D）和癌胚抗原（CEA）对恶性胸腔积液的诊断价值。方法回顺性分析36例结核性胸腔积液和32例恶性胸腔积液患者的胸水D-二聚体和癌胚抗原的检测资料。结果恶性胸腔积液患者胸水的D-二聚体和癌胚抗原的含量均显著高于良性胸腔积液组[（57．43±2．41）mg／L比（12．63±3．23）mg／L，（73．2±6．43）μg／L比（4．15±2．35）μg／L，P〈0．05）]联合检测能提高诊断恶性胸腔积液的敏感度（84．3％）和准确度（86．7％）。结论联合检测胸水D-二聚体和癌胚抗原对鉴别良、恶性胸腔积液具有一定的临床价值。

Objective To explore the diagnostic value of malignant perfusions of D-D and CEA in pleural fluid.Methods The clinical data of the levels of D-D, CEA in pleural effusion of 36 hospitalized patients with benign pleural effusions and 32 patients with malignant perfusion were analyzed retrospectively. Busults malignant pleural effusion of D-dimer and carcinoembryonic antigen levels were significantly higher than benign pleural effusion group [（ 57.43 ± 2.41 ） mg/L vs （12.63 ± 3.23 ） mg/L; （ 73.2 ± 6.43 ） μg/L vs （ 4.15 ±2.35 ）μg/L, P〈 0.05 ）];Joint detection can improve the sensitivity of diagnosing malignant pleural effusion （ 84.3% ） and accuracy （ 86.7% ） significantly higher than those in benign perfusions. Eonelusiong Combined measurement of D-D , CEA in pleural fluid has a preferable clinical value in differential diagnosis of benign and malignant malignant perfusiongs.