乳腺癌浸润发生前后Ang-2的表达及其意义

Ang-2 expression before and after invasion of breast carcinoma and its signifcance

目的:研究Ang-2在乳腺癌发生发展过程中不同浸润阶段的表达及其作用意义。方法:采用免疫组织化学SABC方法,检测42例乳腺浸润癌、15乳腺原位癌、15例早期浸润癌和10例正常乳腺组织中Ang-2的表达情况,并分析其与临床病理特征的关系。结果:Ang-2在正常乳腺组织、乳腺原位癌、早期浸润癌和浸润癌中的表达率分别为20%、40%、66.67%、90.48%。Ang-2在级、级、级乳腺癌组织的阳性表达率分别为73.33%、86.67%、93.33%。结论:Ang-2在乳腺癌组织突破基底膜浸润性生长过程中可能起重要作用;Ang-2在乳腺癌发生发展过程中具有重要作用。

Objective：To study the Ang-2 expression in different invasion stages of breast carcinoma and its significance.Methods：The Ang-2 expression in 42 cases of invasive breast carcinoma,15 cases of breast carcinoma in situ,15 cases of early invasive breast carcinoma and 10 cases of normal breast tissue were detected by SABC immunohistochemical method,and the relationship between Ang-2 and the clinical pathology was analyzed.Results：The Ang-2 positive expression rates of the normal breast tissue,breast carcinoma in situ,early invasive breast carcinoma and invasive breast carcinoma were 20%,40%,66.67% and 90.48%,respectively.The Ang-2 positive expression rates in grade Ⅰ,grad Ⅱ and grad Ⅲ invasive breast carcinoma were 73.33%,86.67% and 93.33%,respectively.Conclusion：Ang-2 may play a critical role in the breast carcinoma tissue penetrating basement membrane and infiltrating growth,and it plays a very important part in the pathology and development of invasive breast carcinoma.