肝病患者血清总胆汁酸和前白蛋白及其它酶类联检的意义

Meaning for investigate the serum level of total bile acids,Prealbumin and other enzymes in patients with liver diseases

目的:探讨肝病患者血清总胆汁酸(TBA)和前白蛋白(PA)及其它酶类水平,并分析其临床意义。方法:检测198例住院肝病患者及57例正常对照血清TBA及PA含量,同时检测丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、碱性磷酸酶(AKP)、总胆红素(TBIL)。结果:各肝病组与正常对照组比较,血清TBA含量均有不同程度升高(P<0.01),而PA含量随着病情加重逐渐降低,尤其急性肝炎、慢性肝炎重度、重型肝炎、肝炎肝硬化时TBA显著升高,PA显著减低,异常率为100%,明显高于其它生化指标。结论:血清TBA和PA更能提前反映肝功能损害,反映肝病的严重程度,是敏感的肝功能指标,对肝病的临床诊断、疗效判断及病情发展有重要参考价值。

Objective：To investigate the serum level of total bile acids（TBA）,Prealbumin and other enzymes in patients with liver diseases,and to analyse its clinical significance.Methods：The Serum total bile acids were measured in 198 patients with liver diseases and 57 normal controls by the method of circle enzyme,the serum ALT、AST、GGT、TBIL were measured in the same time.Results：Various groups of liver disease were compared with comtrol group,serum concentration of TBA and PA were raised in different degree（P〈0.01）,While PA content with illness gradually reduced especially in acute hepatitis、chronic hepatitis in deep degree、heavy hepatitis and liver cirrhosis,the level of seram TBA changed significantly,PA significantly reduced.their abnormity rates（100%）were obvious higher than in the other biochemical index.Conclusion：Serum TBA and PA were sensitive liver function index to reflect severe degree of liver diseases,and it possess important referance value in clinical diagnosis、verdict curative effect and clinical development of liver diseases.