戒烟对慢性阻塞性肺疾病患者临床症状的影响研究

Effects of Smoking Cessation on Clinical Symptoms of Patients with Chronic Obstructive Pulmonary Disease

目的探讨戒烟对慢性阻塞性肺疾病(COPD)患者临床症状的影响。方法对77例目前吸烟的COPD患者进行随机分组:一组除常规治疗外给予戒烟干预(即戒烟组),一组给予常规治疗(即吸烟组)。对所有患者进行问卷调查及临床症状综合评分,至9个月观察期结束再次进行临床症状评分,并统计观察期内急性加重次数。结果戒烟组戒烟9个月后咳嗽、咳痰、呼吸困难等临床症状综合评分较初始值明显下降,差异有统计学意义(P<0.05),与吸烟组比较差异亦有统计学意义(P<0.05)。戒烟组观察期内急性加重次数较入选前9个月明显减少,差异有统计学意义(P<0.05),吸烟组自身前后比较差异无统计学意义(P>0.05)。结论戒烟能够改善COPD患者咳嗽、咳痰、呼吸困难等临床症状,减少其急性加重次数。

Objective To study the effects of smoking cessation on clinical symptoms of patients with chronic obstructive pulmonary disease（COPD）. Methods Totally 77 current smokers with COPD were randomly designed into two groups： one group received smoking interventions besides conventional treatment;the other group only received conventional therapy.All the patients were given questionnaire survey and scores of comprehensive clinical symptom.At the end of 9 months,the same scores were done again,and the frequency of acute exacerbation during the observation period was also recorded. Results The comprehensive scores of such clinical symptoms as cough,expectoration and dyspnea in the smoking cessation group decreased after 9 months,the difference was statistically significant（P0.05）;and compared with the smoking group,the difference was also statistically significant（P0.05）.The frequency of acute exacerbation in the smoking cessation group in 9 months of the observation was decreased than that before the observation,the difference was statistically significant（P0.05）,and no statistically significant difference of the frequency in the smoking group was found after the observation（P0.05）. Conclusion The smoking cessation can improve the clinical symptoms of the patients with COPD such as cough,expectoration,and dyspnea,and reduce the frequency of acute exacerbation.