摘要
目的评价重组人血小板生成素（reconlbinant human thrombopoietin，rhTP0）疗肿瘤放疗所致血小板减少的疗效和安全性。方法放疗所致血小板减少症患者40例，治疗组20例给予rhTPO 15000u，皮下注射每日1次，连续使用；IL-11组给予IL-111．5mg皮下注射，每日1次，连续使用。观察rhTPO对血小板（platelet，PLD、异体输血需求率及时生存质量（QOF）的影响。结果治疗后治疗组血小板水平显著提高，异体输血需求率明显下降，生活质量明显提高。结论rhTPO治疗放疗所致血小板减少症疗效肯定，安全性高，副反应少，能够改善患者生存质量。
Objective To investigate the effectiveness and safety of radiotherapy reduced thrombocytopenia with recombinant human thmmbopeietin （rhTPO）.Methods 40 cancer patients diagnosized as thrombocytopenia were randomly divided into treatment group and control group. In rhTPO group ,rhTPO was given15000u, hypodermic once daily.in IL-11 group IL-11 to 1.5 mg subcutaneous injection, once per day.The influence of the rhTPO and IL-11 on platelet, transfusion rate and quantity of life were observed.Result rhTPO can greatly improve platetet level. The transfusion rate was lower and the Q0F were higher than that of control group. Conclusion rhTPO is effective and safe in treating the thrombocytopenia.rhTPO has the high safety,little characteristics of vice-reaction,can improve the sufferer existence quantity.
作者
靳彩玲
寇小格
路平
JIN Cai-ling,KOU Xiao-ge,LU Ping （Department of Medical Oncolgy,the First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,China）
出处
《医学信息》
2011年第5期1198-1199,共2页
Journal of Medical Information
