系统性红斑狼疮患者甲状腺激素水平变化及其与疾病活动的相关性研究

Clinical Analysis of Abnormal Thyroid Hormone in Systemic Lupus Erythematosus and Their Relationship

目的探讨系统性红斑狼疮(SLE)患者血清甲状腺激素水平及其与疾病活动的相关性。方法检测86例SLE患者(活动期组47例,稳定期组39例)与68例健康体检者(对照组)的血清游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和促甲状腺激素(TSH)水平并进行比较。结果 86例SLE患者血清甲状腺激素水平异常率为44.2%(38/86),显著高于对照组的8.8%(6/39),差异有统计学意义(P<0.05);SLE活动期组患者的血清FT3、FT4水平显著低于对照组和SLE稳定期组,差异均有统计学意义(P<0.05);而SLE稳定期组的血清FT3、FT4水平与对照组比较差异无统计学意义(P>0.05);SLE患者血清甲状腺激素水平异常组的SLE疾病活动指数(SLEDAI)评分、SLE损伤指数(SLICC/ACRD I)均显著高于甲状腺激素水平正常组(P<0.05)。结论 SLE患者可以合并甲状腺功能受损,血清甲状腺激素水平降低与病情活动及脏器损害有关,对疾病评价、治疗及预后有一定的指导价值。

Objective To evaluate the concentration of thyroid hormone in systemic lupus erythematosus（SLE） patients and the association with the disease activity.Methods The serum concentration of thyroid hormone（FT3,FT4,TSH） in 86 SLE patients（47 in active phase,39 in stable phase） and 68 healthy controls were measured.Results SLE patients had a significantly higher prevalence of thyroid dysfunction（44.2%） than the control group（8.8%）（P0.05）.Significantly lower FT3,FT4 levels were detected in SLE patients in active phase than control group and SLE patients in stable phase（P0.05）.While no significant difference was found in the serum concentrations of FT3,FT4 between stable SLE patients and the healthy controls.（P0.05）.The level of systemic lupus erythematosus disease activity index（SLEDAI）and Systemic Lupus International Collaborative Clinics/American College of Rheumatology Damage Index（SLICC/ACRDI） in thyroid hormone abnormal group was significant higher than the normal group（P0.05）.Conclusion The abnormal of thyroid hormone could be seen in the SLE patients.The decreasing of thyroid hormone has a close relationship with the disease activity and organ damage in SLE patients,and it is valuable in evaluating and treating the SLE patients.