构树的化学特性和药理作用研究进展

Research progress of chemical constituents and pharmacological activity of Broussonetia papyrifera at home and abroad

综述了国内外对构树(Broussonetiapapyrifera)化学成分和药理作用的研究进展,现代研究表明:从构树中分离得到的化合物对超氧化物歧化酶显示出较高的抑制活性,能够抑制酪氨酸酶的活性,具有强烈抑制类脂氧化作用,桦木醇和桦木酸对抗疼痛和抗炎效果较好,对凝血酶引起的血小板凝聚亦有强烈的抑制作用,具有很强的抗真菌作用,可显著抑制IIA和V型sPLA2s的活性,且对HepG2细胞有较高的细胞毒作用,还有些化合物对α-葡萄糖苷酶的抑制活性检测结果具有较好的α-葡萄糖苷酶抑制活性.该属植物中已发现的各类化学成分及其药理作用可为开发新药提供依据.

Broussonetia papyrifera which belong to moraceae Broussonetia,is a deciduous tree and a multi-functional species extensively applied in the papermaking,feed,medicine and so on.Recently studies indicated that some compounds isolated from B.papyrifera exhibited rather inhibition on superoxide anion dismutase,the tyrosinase,lipid peroxidation,betulin and betulinic acid anti-inflammatory and assuagingpain.And some compounds have cytotoxicity effect on HepG2 cells,displayed significant inhibitory activity with IC50.To further study the chemical constituents and pharmacology of the family,we reviewed all known chemical constituents isolated and their pharmacology,and provided a reasonable foundation for the new drug discovery.