压宁定注射液治疗高血压急症的疗效观察

Observation of clinical efficacy of injecting urapidil on hypertensive emergency

目的 观察压宁定注射液对高血压急症的降压作用。方法 对 12例高血压急症给予压宁定注射液2 5mg加入 5 %葡萄糖注射液 2 0ml静注 ,观察注射后 5、10、15、30、6 0和 12 0min的血压、心率、临床表现及不良反应。结果 用药后 5min收缩压和舒张压即开始下降 ,但以 10、15、30、6 0、12 0min下降最明显 (P <0 0 1) ,心率略有下降(P >0 0 5 ) ,总有效率 91 7%。结论 压宁定注射液对高血压急症有较好疗效 ,特别适用于高血压急症合并心动过速或合并急性左心衰竭的患者。

Objective To investigate the clinical efficacy of urapidil in 12 patients with hypertensive emergency. Methods Blood pressure(BP) and heart rate(HR) were measured at 5,10,15,30,60,120 min after 25mg urapidil which was dissolved in 20 ml 5% glucose was injected intravenously. Results\ Systolic BP and diastolic BP decreased significantly after urapidil was injected. It took effect at 5 min after injection, the peak effect arrived at 10 min and lasted for 2h. Total effective rate was 91.7%. Condusion Intravenous urapidil is an effective acute antihypertensive drug. It is applicable to the patients with hypertensive emergency. It may also be used to treat those who was complicated with tachycardia or left heart failure.