小儿手足口病免疫球蛋白与超敏C反应蛋白的检测分析

Analysis on Testing Serum Immunoglobulins and hs-CRP in Children with Hand-foot-mouth Disease

目的探讨手足口病患儿病变早期的免疫球蛋白与超敏C反应蛋白(hs-CRP)的水平变化及临床意义。方法检测60例手足口病患儿入院时免疫球蛋白(IgG、IgM、IgA)与hs-CRP水平,同时选择60例健康儿童作为对照组。结果手足口病患儿病变早期IgM水平明显高于对照组,差异有统计学意义(t=5.22,P<0.05),IgG、IgA水平明显低于对照组,差异有统计学意义(t值分别为2.99和3.49,P<0.05),hs-CRP水平明显高于对照组,差异有统计学意义(t=5.06,P<0.05)。结论 IgM与hs-CRP水平明显高于对照组,IgG、IgA水平明显低于对照组,联合检测以上指标对手足口病的早期诊断具有一定的临床价值。

Objective To explore serum immunoglobulins and hs-CRP′s level and clinical significance on the early stage of HFMD in children.Methods Testing serum immunoglobulins（IgG,IgM,IgA） and hs-CRP′s level on admission of 60 HFMD children patients,and selecting 60 healthy children as control group.Results Level of IgM in observation group on HFMD′s early stage were significantly higher than control group（t=5.22,P0.05）,yet level of IgG and IgA were significantly lower than control group（t=2.99 and t=3.49,P0.05）,and level of hs-CRP were significantly higher than control group（t=5.06,P0.05）.Conclusion The level of IgM and hs-CRP in observation group were significantly higher than control group,yet level of IgG and IgA were significantly lower than control group,and combined testing method has some clinical values to early diagnosis of HFMD.