摘要
目的评价氨基末端B型利钠肽前体(NT-proBNP)联合血红蛋白(Hb)测定对充血性心力衰竭(CHF)患者病情的评估价值。方法测定107例CHF住院患者入院时的NT-proBNP、Hb水平等指标,对患者进行心功能分级,观察其住院期间心脏不良事件的发生情况。结果贫血患者的NT-proBNP、Hb水平与无贫血患者比较,差异有统计学意义(P<0.05);NYHA分级不同,患者的NT-proBNP、Hb水平比较,差异有统计学意义(P<0.01)。贫血且NT-proBNP≥中位数的患者,中重度心力衰竭发生率(100.0%)及住院期间心脏不良事件发生率(52.9%)显著高于单独贫血患者(70.6%和23.7%)及NT-proBNP≥中位数患者(70.9%和20.0%),差异有统计学意义(P<0.05)。结论联合检测NT-proBNP及Hb可以更全面地评估CHF患者的病情和预测住院期间心脏不良事件的发生。
Objective To evaluate the value of combined detection of N-Terminal ptro-brain natriuretic peptide（NT-proBNP）and hemoglobin（Hb） in patients with congestive heart failture.Methods The level of plasma NT-proBNP and Hb of 107 patients with congestive heart failture was measured when they were admitted.The NYHA heart function was assessed and the incidence of adverse cardic events was observed during the period of in-hospital.Results The level of NT-proBNP and Hb in patients with anemia had statistical difference compared with that in patients without anemia（P0.05）.Patients with different NYHA had statistical difference in NT-proBNP and Hb levels（P0.05）.The incidence of moderate and severe heart failure of patients with anemia and NT-proBNP levels above the median were 100.0%,while the incidence rate of adverse cardic events were 52.9%,both higher than those of patients with anemia or NT-proBNP levels below the median alone（P0.05）.Conclusion The combined detection of NT-proBNP and hemoglobin can assess more comprehensively the cardiac functional grading and major adverse cardiac events of patient with congestive heart failure during the period of in-hospital.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第5期500-502,共3页
Chinese General Practice
