病脑患儿红细胞免疫调节因子、IL—2R、NK细胞的动态观察

A dynamic obseration of the immune regulative factor of red cell,IL-2R and NK cell in children with acute viral encephalitis

⑶目的⑶探讨病脑患儿细胞免疫改变⒙为治疗提供依据⒚方法⑶采用红细胞 Ｃ３ｂ 受体花环抑制率⒉ Ｒ Ｆ Ｉ Ｒ⒕⒙促进率⒉ Ｒ Ｆ Ｅ Ｒ⒕试验的方法及单克隆抗体间接免疫荧光法检测了 ３６ 例病脑患儿、３５ 例健康儿童的 Ｒ Ｆ Ｉ Ｒ、 Ｒ Ｆ Ｅ Ｒ、 Ｉ Ｌ－ ２ Ｒ及 Ｎ Ｋ 细胞⒚结果⑶急性期 Ｒ Ｆ Ｉ Ｒ 下降⒙ Ｒ Ｆ Ｅ Ｒ、 Ｉ Ｌ－ ２ Ｒ及 Ｎ Ｋ 细胞增高⒙与对照组相比差异显著⒉ Ｐ＜ ０．００５⒕⒙恢复期 Ｒ Ｆ Ｅ Ｒ、 Ｉ Ｌ－ ２ Ｒ 和 Ｎ Ｋ 细胞均较急性期显著下降⒉ Ｐ＜ ０．０５⒙ Ｐ＜ ０．００１⒕⒙ Ｒ Ｆ Ｉ Ｒ

Objective:To research the change of cell immune with acute viral encephalitis children and provide foundation for the treatment.Methods:With serum rosette forming inhibitory rate (RFIR)and enhancing rate(RFER) of red cell C 3b receptor and indirect fluoresent antibody technigues.We obserated serum RFIR.RFER IL-2R and NK cell of 36 children with acute encephalitis and 35 normal children.Results:In the acute stage,RFIR was Signifi-cantly lower in the patients than that of the normal controls(P<0.05),REFR、IL-2R and NK cell were Significantly elevated in the patients compared with normal controls(P<0.05),In the recoverable stage.RFER、IL-2R and NK cell were Significantly lower than that of the acute stage (P<0.05 P<0.001).Conclusion:The pathoyenic mechanism of acute viral encephalifis has relation to the change of cell immune of self-preservation mechanism.