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小分子抗癌新药nutlin-3的合成新法研究 被引量：2

Research of Synthetic Methods to Nutlin-3,a Small Molecules Anticancer Drug
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摘要 以4-甲氧基-2-羟基苯甲醛和对氯苯甲醛为原料,采用7步反应初步合成了小分子抗肿瘤药物nutlin-3,TLC检测每一步反应,总收率40%。对中间体和目标产物的结构和纯度进行了IR和1H NMR表征。 Nutlin-3 is A small molecules anticancer drug,synthesized from the starting materials 4-methoxy-2-hydroxybenzaldehyde and its seven steps in chlorobenzaldehyde is listed in this paper.Every step of the reaction was tested by TLC and the total yield was 40%.The structure and purity of intermediate products was characterized by IR and 1H NMR spectra.
作者 陈芬 覃宇 丁四海
机构地区 武汉职业技术学院生物工程学院
出处 《武汉职业技术学院学报》 2011年第1期75-78,共4页 Journal of Wuhan Polytechnic
关键词 Nutlins 咪唑啉类似物 抗肿瘤 合成 表征 nutlins imidazoline analogues anticancer synthesis indicate
分类号 R979.1 [医药卫生—药品]
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参考文献6

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二级参考文献34

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武汉职业技术学院学报
2011年 第1期

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