摘要
目的:通过检测CD44v6和P53在肾细胞癌(RCC)中的表达,探讨它们与肾癌的发生、病理分级、临床分期的关系。方法:免疫组织化学方法检测40例RCC石蜡标本中CD44v6和P53的蛋白表达,并分组进行统计学分析。结果:CD44v6与P53在RCC中表达率与对照组相比明显升高(P<0.05),但不同病理分级、临床分期之间差异无显著性(P>0.05)。CD44v6和P53表达存在正性相关,但两者在RCC中表达率差异存在显著性,CD44v6表达率高于P53的表达率(P<0.05)。结论:CD44v6和P53高表达可能成为肾癌的恶性表型之一,但两者与病理分级、临床分期无明显相关性。
Objective： To investigate the expression of CD44v6 and P53 in renal cell carcinoma（RCC）. Methods ： Protein expression of CD44v6 and P53 in 40 RCC tissues wasexamined by immunohistochemical assay. Results： CD44v6 and P53 showed an overexpression ratein RCC, but there were no significant differences among different pathological grades and clinical stages. A positive correlation was detected between CD44v6 and P53, but the expression rate of CD44v6was higher than that of P53. Conclusion： Both the expression of CD44v6 and P53 were malignant phenotypes in RCC, but there are no correlation at different pathological grades and clinical stages.
