摘要
目的观察肝癌部分肝叶切除术后残肝断面5-氟尿嘧啶缓释剂(商品名:中人氟安)植入对肝癌转移复发的影响及其不良反应。方法 63例肝癌拟手术者随机分为2组:I组(n=32)为普通化疗组,患者于肝癌肝叶部分切除术后行常规化疗;II组(n=31)为缓释剂组,患者于肝癌肝叶部分切除术中残肝断面植入5-氟尿嘧啶缓释剂局部化疗。2组患者均随访1年,观察其不良反应、肿瘤复发率及患者死亡率。结果术前2组患者肝功能无明显差异(P>0.05),术后各观察点II组患者ALT、AST、TBL、PT、AFP水平均明显低于I组(P<0.05);II组患者术后复发转移率明显低于I组(P<0.05);II组患者的并发症发生率及死亡率均明显低于I组患者(P<0.05)。结论术中残肝断面植入5-氟尿嘧啶缓释剂疗效明显,能够减少肿瘤复发和转移,增加患者的耐受性与依从性,可有效防止肝癌术后转移复发,值得临床推广应用。
Objective To evaluate the effect of a local chemotherapy with sustained--release 5--fluorouracil during operation. Methods 63 patients diagnosed with Liver Cancer were devided into two groups： I（n=32）, ordinary chemotherapy group, patients with conventional chemotherapy after operation; II（n=31）, patients with sustained-- release 5--fluorouracil in operation. The two groups of patients were follow--up a year, observe the reaction, disease and mortality from cancer patients. Results The two groups patients＇ liver function were no difference before operation（P〉0.05）. The II group＇ s ALT. AST, TBL. PT. AFP were much lower than I group（P〈0.05）：The transfer rate of group II was much lower than group 1 （P〈0.05）;The incidence and mortality of group It were much lower than group I （P〈0.05）.Conclusion The treatment of sustained--release 5--fluorouracil during operation can effectively reduce the transfer rate, recurrence and mortality of liver cancer patients, increase the patients＇ compliance and tolerance, it may be a new therapy for patients with liver cancer after hepatectomy.
出处
《中国卫生产业》
2011年第1期37-38,40,共3页
China Health Industry
